Endometriosis

A Scoping Systematic Review of Cannabis Use in Endometriosis

Kindha McLaren, Simon Erridge, Mikael H. Sodergren (December 2025)

Thirteen studies, including 4 ongoing studies, were included. All nine completed studies, with 1,787 participants, were cross-sectional. Pain (57.3%–95.5%) was the most common indication for cannabis use, followed by sleep and gastrointestinal distress (15.2%–78.5%). Cannabis was most commonly inhaled (51.6%–80.3%) or ingested (25%–76.9%). Eight (61.5%) studies asked about participants' perception of the efficacy of cannabis. These utilised a range of methods preventing pooling of results. However, most reported improvement in at least a proportion of their studied population. Adverse events were reported by 10.2% to 52.0% of patients, with the most common being “feeling high” (euphoria) and a dry mouth.

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