The Consumption of Cannabis by Fibromyalgia Patients in Israel

George Habib and Irit Avisar  (July 2018)

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An Internet-based questionnaire was posted to three large fibromyalgia Facebook groups in our country. The questionnaire was anonymous and included demographic, clinical, and cannabis-related questions, including acquisition of a license for medical cannabis (MC) method and amount of cannabis consumption; need to buy cannabis beyond the medical allowance; effect of cannabis on pain, sleep, depression, and anxiety; adverse effects of cannabis; feelings of dependence on cannabis or other meds; the involvement of family members; tendency to drive after using cannabis; and employment and social disability status. Out of the fibromyalgia social media groups’ 2,705 members, 383 participants (~14%) with fibromyalgia diagnosed by a rheumatologist responded to the questionnaire.

Medical Cannabis for the Treatment of Fibromyalgia

George Habib, MD, MPH and Suheil Artul, MD  (January 2018)

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Fibromyalgia is a chronic pain syndrome, characterized by chronic musculoskeletal pain, fatigue, and mood disturbances. There are nearly no data on the effect of medical cannabis (MC) treatment on patients with fibromyalgia. Medical cannabis treatment had a significant favorable effect on patients with fibromyalgia, with few adverse effects.

Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes

Ethan B. Russo  (June 2016)

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Medicine continues to struggle in its approaches to numerous common subjective pain syndromes that lack objective signs and remain treatment resistant. Foremost among these are migraine, fibromyalgia, and irritable bowel syndrome, disorders that may overlap in their affected populations and whose sufferers have all endured the stigma of a psychosomatic label, as well as the failure of endless pharmacotherapeutic interventions with substandard benefit. The commonality in symptomatology in these conditions displaying hyperalgesia and central sensitization with possible common underlying pathophysiology suggests that a clinical endocannabinoid deficiency might characterize their origin.

Cannabinoids for fibromyalgia

Winfried Hauser, Brian Walitt, Petra Klose, Mary-Ann Fitzcharles  (May 2015)

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Current pharmacological treatment options for fibromyalgia afford only modest benefit for most patients, often with side effects that outweigh the benefits (Häuser 2014b). A need therefore exists to explore other treatment options, with different mechanisms of action and from different drug categories, for treatment of the constellation of symptoms that characterise fibromyalgia. The cannabinoid system is ubiquitous in the animal kingdom, with multiple functions that move the organism back to equilibrium. These stabilising effects for the organism, including modulation of pain and stress, suggest that manipulation of this system may have therapeutic potential for the management of fibromyalgia (Pacher 2006).

Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?

Ethan B. Russo  (February 2004)

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Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors supporting therapeutic efficacy in acute and preventive migraine treatment. Cannabinoids also demonstrate dopamine-blocking and anti-inflammatory effects. AEA is tonically active in the periaqueductal gray matter, a migraine generator. THC modulates glutamatergic neurotransmission via NMDA receptors. Fibromyalgia is now conceived as a central sensitization state with secondary hyperalgesia. Cannabinoids have similarly demonstrated the ability to block spinal, peripheral and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS and related disorders.